This review summarizes current knowledge, admittedly incomplete, on neuropathic itch caused by diseases of the brain, spinal cord, cranial or spinal nerve-roots, and peripheral nerves. Dermatologists need some familiarity with the most common neuropathic itch syndromes to initiate diagnostic testing and to know when to refer to a neurologist. However, itch is a neural sensation and some forms of chronic itch are the presenting symptoms of neurological diseases. Patients with chronic itch are diagnosed and treated by dermatologists.